Stem Cell

Stems Cell

Our cutting-edge stem-cell regenerative therapies allow us to offer minimally-invasive treatments for individuals suffering from a variety of inflammatory and degenerative conditions, including Leukemia, Lymphoma, Parkinson's disease, Alzheimer's disease, Multiple Sclerosis, brain and spinal cord injury, heart disease, blood-cell formation, missing teeth, hair loss, blindness and vision loss, wound healing, infertility, HIV/AIDS, and many others. We offer non-embryonic therapies which allow us to harvest and deploy your own adult stem cells within the same minimally invasive treatment.

While stem cell therapies may seem to have appeared overnight, they have been practiced for some time prior to the recent burst in new applications and stem cell sources. The most recent developments in stem cell medicine have brought exciting new opportunities and shown great potential for improving patient outcomes – especially over the long-term.  


What Are Stem Cells?

Stem cells are primitive cells in our body serving as a reservoir, able to replenish itself and differentiate into a wide range of specialized cells, in order to replace damaged cells and regenerate tissue. They have innate intelligence, able to home in to areas of hypoxia and inflammation, secrete bioactive molecules that exert local and systemic effects, reduce inflammation, and recruit local cells to assist in the reparative process.


Every cell in our body can trace its origin to the ultimate stem cell – a fertilized egg. Each cell division moves the cells down a path to their final cell type such as cells of muscle, nerve, and various organs. All along this journey cells make commitments that are typically irreversible.  This implies that any cell type or tissue in our body may require stem cells for regeneration. Properly harnessed, stem cells have the potential to repair or reverse an incredibly broad range of diseases, conditions, injuries and more. To name a few, injectable stem cell products have been used to successfully treat joint problems, muscle and tendon conditions, neurological diseases such as Parkinson’s or stroke, autoimmune diseases, wounds such as diabetic ulcers or burns, hair loss, wrinkles, lung conditions and heart disease. In treating an astonishing number of debilitating conditions, stem cells truly change lives – often permanently.


Where Are These Stem Cells?

Stem cells exist in varying forms in numerous places throughout the body, although with a tendency to decline in number throughout our life cycle. Our own natural wound repair system employs stem cells in regenerating a variety of tissues. Stem cells are more abundant in bone marrow, fat tissue, and circulating blood; it is from these sources the body often recruits stem cells when they are needed. Stem cells are especially abundant at birth, in tissues present in umbilical cords and placenta, which is why many parents choose to privately store umbilical cord tissue and cord blood when their babies are born. Membranes from placenta have been used to treat burns and other wounds for over a century and bone marrow transplants have been routine for decades as well. 


Adult Tissue as Stem Cell Source

More recently, stem cells from a patient’s own fat, bone marrow, and circulating blood have been used to treat a variety of common conditions. For example, in the case of joint problems that require replacement or repair of cartilage, concentrated and directed doses of one’s own stem cells have been shown to be more effective and long-lasting than widely practiced alternatives using PRP (platelet rich plasma) or cortisol injections. Acquiring stem cells from an adult’s blood requires many sessions and expensive processing, to harvest a useful number of therapeutic cells. Using bone marrow increases yield and requires only one session. Harvesting stem cells from fat has exciting applications and has shown efficacy for treating a variety of conditions.


Birth Tissue as Stem Cell Source

Stem cells harvested from tissues typically discarded at birth (e.g. placenta, umbilical cord) is another rich source of stem cells that boast some unique properties that set them apart from adult stem cells. While adult stem cells need to be a match (much like blood transfusions) to avoid rejection by the recipient’s immune system, stem cells of umbilical cord and placental origin do not need to be matched. This is because the young cells present in these birth tissues have not fully developed the surface proteins (“HLA markers”) found on the outer membranes of adult cells, and thus are able to “fly under the radar” of the recipient’s immune system. This immune-privileged status makes the transplant an easier task in a number of ways and can speed up the stem cell therapy: instead of harvesting the cells from the patient, the doctor is able to open the stem cell medicine cabinet to administer the dose that is needed. This also removes some of the limitations for increasing the dosage of stem cells. These tissue transplant products are not classified as drugs by the FDA as long as they are “minimally manipulated.”


Stem cells harvested from birth tissues have another unique advantage: These cells are young and have been shown to be more therapeutically active. While all of the mechanisms by which stem cells benefit the healing and regeneration processes are not fully known, we do know that the cells produce and secrete cytokines and growth factors. When younger stem cells are compared to adult stem cells, they show a significant increase in the secretion of growth factors, speed of differentiation, the total number of future cell divisions before eventual cell death, and other cell activity benchmarks. All of these factors likely contribute to the observed greater plasticity of younger stem cells (i.e. the ability to differentiate into a more diverse range of cell types).


Birth Tissue - 

Amniotic Membrane Injectable amniotic membrane products have been rapidly advancing in quality and number of uses in the last five years, and show greater long-term efficacy than PRP (platelet rich plasma) or cortisol injections. Products made from membranes (excised from placenta that are properly tested and harvested from C-section births from mothers undergoing the recommended blood-borne pathogen panel) can be ordered for overnight delivery from a number of distributors. Using these stem cells does not require matching because, while the chorionic (maternally facing) membrane presents HLA markers, the fetal-facing membrane (amnion) is immune-privileged and can be used in allogeneic applications (transplantation from a different individual).


Birth Tissue - Umbilical Cord Blood

Cord blood contain hematopoietic CD34+ cells that have for decades been used to treat the same panel of conditions for which bone marrow has been used, and they have more mature HLA presentation than the cells from the cord tissue.  There is evidence, however of a more naïve progenitor cell present exclusively in cord blood.  The hematopoietic cells will also help with angiogenesis (generating blood vessels) thus help with blood supply to the repaired tissue.


Birth Tissue - Umbilical Cord Tissue

The newest stem cell product derived from birth products is from umbilical cord tissue.  The umbilical cord is a dense source of MSCs. MSCs (mesenchymal stem cells) have the capability to differentiate into bone, cartilage, fat, cardiac muscle cells, skeletal muscle fibers, renal cells, and have even been shown to differentiate into cells of ectodermal origin (e.g. neurons) and endodermal origin (e.g. hepatocytes and pancreatic cells).  Because the stem cell-rich Wharton’s Jelly in the umbilical cord is protected by a sheath, the cord can be obtained from vaginal deliveries and subsequently sterilized, processed, and tested.


*All donated cords are the by-products of normal, healthy births. Each cord is carefully screened for sterility and infectious diseases under American Association of Blood Bank standards.


In Conclusion

Adult stem cells (i.e. “non-embryonic” in origin) can be harvested from various sources including bone marrow, adipose tissue, amniotic fluid, placenta and umbilical cord. Among these, umbilical cord-derived cells offer many advantages, including abundance, youthfulness, easy harvesting, no need for HLA matching, excellent safety record, exceptional ability for replication and differentiation, and robust angiogenic potential. 


Although autologous stem cell transplantation (using a person’s own stem cells) is currently the most utilized form of stem cell therapy, as it avoids the risk of graft vs. host immune response, this method has significant drawbacks in the aging and chronically ill populations, because in this population, both the number and quality of stem cells have declined, limiting their regenerative capabilities. Even among the young and healthy adult population, stem cells obtained from bone marrow or adipose tissue will have lower differentiation potential, shorter telomeres (end sequences that protects the chromosomes), and less generations of offspring compared to the stem cells of umbilical cord origin. 

Choosing Stem Cells

And as one can see, stem cell products available to physicians for treating patients can be obtained from a variety of sources and manufacturers. There are differences in quality of the source material and the manufacturing process. It is important to investigate the purity, quality, and viability of the stem cell product to achieve the best results. While some products like amniotic membranes used for dressing burns can benefit a patient even when there are no living cells present (due to the scaffolding effect) other products like injectable stem cells used for treating joints or stroke are more effective when the donor cells are living and healthy. Some stem cell companies provide cell assay results that define the product and verify the presence of healthy living cells. Some products that have been freeze-dried, are stored at room temperature, or are suspended in solutions that aren’t conducive to cell stability may contain scaffolding, growth factors, and other things but are less likely to provide any living cells.  

Your doctor is likely to have more information about the emerging stem cell therapies and can guide you in your search for the best that modern medicine has to offer. More developments and more successes are being reported every day in this rapidly progressing area of medicine.  It is a wonderful time to be alive when so many of the things that could rob us of our vitality can now be treated in effective and often lasting ways.

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ADVANCED CELL REJUVENATION PROCEDURES

RegenDrip and RegenShot can be offered by most Physicians within their practice. However, advanced conditions may require a more specialized treatment protocol. BRT has therefore developed BRT Platinum Partners who are experts in advanced Cell Rejuvenation procedures.

You can simply refer your clients to one of our Platinum Partners. Some of the advanced conditions which your clients can referred for are listed below.

Orthopedic Conditions

Chronic arthritis and joint injuries can be debilitating, and its treatment may require specialized assessment and local injections. We have aligned ourselves with some of the world’s leading orthopedic surgeons specializing in Cell Rejuvenation treatment.

Autoimmune Conditions

Autoimmune conditions are widespread, including more than 80 chronic and often disabling disorders. Stem cells (especially MSC’s) have remarkable immune-modulatory effects that has shown tremendous benefits in improving autoimmune conditions.

Stem Cells Can Also Help With

Heart Disease

Our heart pumps out around 2,000 gallons of oxygen-rich blood throughout the body each day. Modern day heart and vessel disease are rampant and the consequences can be devastating. Cell Rejuvenation Therapy has shown great promise in clinical studies in the treatment of cardiovascular diseases.

Dermatological Conditions

Many dermatological conditions are autoimmune in nature, such as psoriasis, scleroderma, SLE, etc., and MSC’s immune-modulatory effects can prove to be particularly helpful. Chronic non-healing wounds are particularly challenging, yet MSC’s have be shown to promote wound tissue remodeling and healing, and can be a powerful tool in chronic wound treatment. 

Neurological Conditions

In cases of diseases such as Parkinson’s Disease, Multiple Sclerosis, Alzheimer’s or other neurodegenerative disease, Cell Rejuvenations treatment can slow the degenerative progression while restoring blood flow to the brain and repairing or replacing damaged tissue.

IV Drip Stem Cells

Learn More about IV Stem Cell Therapies

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The California Wellness Institute

“The California Wellness Institute is not offering stem cell therapy as a cure for any condition, disease, or injury.  No statements or implied treatments on this website have been evaluated or approved by the FDA.  This website contains no medical advice.  All statements and opinions provided by this website are provided for educational and informational purposes only and we do not diagnose or treat via this website or via telephone.  Dr. Rajaratnam is offering patient funded research to provide individual patients with Stromal Vascular Fraction that contains their own autologous stem cells and growth factors and we provide surgical procedures only and are not involved in the use or manufacture of any investigational drugs.

Dr.Rajaratnam M.D.

Dr. Rajaratnam M.D. does not claim that any applications, or potential applications, using autologous stem cells are approved by the FDA, or are even effective. We do not claim that these treatments work for any listed nor unlisted condition, intended or implied. It’s important for potential patients to do their own research based on the options that we present so that one can make an informed decision. Any decision to participate in our patient funded experimental protocols is completely voluntary. 

Attention

If you have ANY concern with stromal vascular fraction, any of our products, methods, website, or technique and think we may be violating any U.S. law, please contact us so that we can investigate the matter or concern immediately.

- Eugene Rajaratnam, M.D., F.A.C.S.”

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